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Of the 229 patients who were initially evaluated, 186 met the entry criteria. In the lorazepam group, 3 of 100 patients (3 percent) had a second seizure, as compared with 21 of 86 patients (24 percent) in the placebo group (odds ratio for seizure with the use of placebo, 10.4; 95 percent confidence interval, 3.6 to 30.2; P<0.001). Forty-two percent of the placebo group were admitted to the hospital, as compared with 29 percent of the lorazepam group (odds ratio for admission, 2.1; 95 percent confidence interval, 1.1 to 4.0; P<0.02). Seven patients in the placebo group and one in the lorazepam group were transported to an emergency department in Boston with a second seizure within 48 hours after hospital discharge. Treatment with intravenous lorazepam is associated with a significant reduction in the risk of recurrent seizures related to alcohol. |
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alcohol
alcoholic withdrawal states,DT's,convulsions,etc.
benzodiazepine
emergency room
lorazepam
prevention of neurologic disorders
seizure
seizure,prevention of
seizure,withdrawal
treatment of neurologic disorder
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